Dickkopf-3 (Dkk3), a member of a family of modulators of the Wnt signaling pathway, is a stress-induced, tubular epithelial cell-derived regulator of tubulo-interstitial fibrosis. Specific silencing of Dkk3 in renal tubular epithelial cells by genetic deletion or antibody blockade reduced tissue scarring in animal models of chronic kidney injury, thereby preventing loss of kidney function.

Schunk SJ, et al. WNT-β-catenin signaling - a versatile player in kidney injury and repair.

Nat Rev Nephrol 2021; 17: 172-184

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Based on ELISA technology, a special IVDR-certified test was developed for the measurement of Dkk3 in urine. The test is produced and marketed by our partner Immundiagnostik AG:

https://www.immundiagnostik.com/de/portfolio/testkits/y1001/method:elisa

ELISA for the measurement of human Dkk3 in urine (ReFiNE^®)

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01) Assessment: The result of the Dkk3 measurement in the urine should always be interpreted in conjunction with the kidney function, i.e. eGFR. If Dkk3 in the urine is constantly elevated, there is a high probability of progressive (chronic) kidney damage
02) Indication: Non-invasive diagnosis of progressive kidney damage in patients at risk
03) Method: ELISA
04) Sample material: 1-2 ml spontaneous urine
05) Sample transportation: Standard transport (refrigerated), alternatively deep-frozen with sample storage for 24 hours
06) Interpretation of the test results: see Zewinger et al, J Am Soc Nephrol 2018; 29: 2722-2733
07) Benefit: Active or progressive kidney damage of various causes can be diagnosed at an early stage. Both the course of kidney damage (progression) and the effect of specific therapy to reduce progression can be better controlled and the procedure for high-risk patients is optimized (better therapy adherence!)
08) Certification: IVDR / CE